Effect of Phoenix dactylifera extracts on anti-inflammatory, anticoagulant, analgesic and antidepressant activities.pdf

Phoenix dactylifera L. is a medicinal plant and it is extensively used in the prevention and cure of chronic diseases. The present study investigated the effects of antidepressant, analgesic, anti-inflammatory and anticoagulant activities in rats by P. dactylifera extracts. Methanolic extracts of P. dactylifera fruit extract (PDF), P. dactylifera seed extract (PDS) and P. dactylifera fruit and seedextract mixture (PDM) for antidepressant, analgesic, anti-inflammatory and anticoagulant activities inSprague Dawley rats at 300, 200 and 100mg/kg body weight. Results indicated that TST and FSTshowed that rats struggling with efforts and immobility time were higher in PDS, while locomotory behavior and immobility time were significantly increased in PDS and PDM, respectively. All extracts showed good antidepressant activity, but PDS showed the highest value, while analgesic activity and edema reduction were demonstrated by PDF. In addition, PDM revealed significant anticoagulant activity and moderate activity in PDF. We can conclude that Phoenix dactylifera extracts prolong theclotting time and have the potential to reduce the platelet aggregations, depression and inflammation.Further studies needed to determine the active components responsible for pharmacological effects.

海枣（Phoenix dactylifera L.）是一种药用植物，被广泛应用于慢性疾病的防治。本研究探究了海枣提取物对大鼠的抗抑郁、镇痛、抗炎及抗凝血活性的影响。实验分别采用海枣果肉甲醇提取物（PDF）、海枣籽甲醇提取物（PDS）以及海枣果籽混合甲醇提取物（PDM），以300、200及100mg/kg体质量的剂量，在斯普拉格-道利（Sprague Dawley，SD）大鼠中开展抗抑郁、镇痛、抗炎及抗凝血活性评价。结果显示，悬尾实验（TST）与强迫游泳实验（FST）表明，PDS组大鼠的挣扎行为与不动时长均更高；PDS组的运动行为及PDM组的不动时长均显著升高。所有提取物均表现出良好的抗抑郁活性，其中PDS的抗抑郁效果最为显著；PDF则展现出最优的镇痛活性与水肿缓解效果。此外，PDM表现出显著的抗凝血活性，PDF则呈现出中等强度的抗凝血活性。综上，海枣提取物可延长凝血时间，且具有降低血小板聚集、缓解抑郁与炎症的潜力。未来仍需进一步开展研究，以明确其发挥药理活性的具体活性成分。