A Gut-Brain Connection: Probiotics L9 and A6 Offer New Insights into AD Prevention

Accumulating evidence suggests that probiotics affect the microbial-gut-brain axis in a way that can prevent and treat Alzheimer's disease (AD). However, the mechanism underlying the therapeutic effects still needs to be further investigated. This study aimed to examine the alleviating effect of Lacticaseibacillus paracasei L9 (L9) and Bifidobacterium animalis subsp. lactis A6 (A6) and possible mechanism in mice with AD.

越来越多的研究证据表明，益生菌可通过调控微生物-肠-脑轴（microbial-gut-brain axis）实现阿尔茨海默病（Alzheimer's disease, AD）的预防与治疗。然而，其发挥治疗作用的具体分子机制仍有待进一步阐明。本研究旨在探究副干酪乳杆菌L9（Lacticaseibacillus paracasei L9，L9）与动物双歧杆菌乳亚种A6（Bifidobacterium animalis subsp. lactis A6，A6）对阿尔茨海默病模型小鼠的缓解效应及其潜在作用机制。