Waterborne Risperidone Decreases Stress Response in Zebrafish

The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish.

多项研究均已证实地表水体与市政废水中存在药物及其代谢产物，但目前学界对其给水生生物造成的影响尚未形成充分认知。本研究针对抗精神病药物利培酮（risperidone）的急性暴露对斑马鱼应激与行为反应的影响展开了探究。结果明确显示，中等浓度的利培酮可抑制斑马鱼的下丘脑-垂体-肾间轴（hypothalamic-pituitary-interrenal axis），并在斑马鱼中表现出类抗焦虑效应。本研究所呈现的数据表明，这类抗精神病药物在水生环境中的残留可改变斑马鱼的神经内分泌与行为谱特征。