Array-based genome-wide transcriptome analysis of the left atrial appendage for the difference between SR maintenance group and AF recurrence group

Atrial fibrillation (AF), which causes cardiogenic cerebral infarction, is the most common type of persistent arrhythmia, and its incidence increases with age. We performed a radial procedure using an RF ablation device to restore sinus rhythm (SR). Microarray analysis of the difference between the SR maintenance group (n=4) and the AF recurrence group (n=3) after Maze surgery was performed using FFPE samples of left atrial appendage.

心房颤动（Atrial fibrillation, AF）是引发心源性脑梗死的最常见持续性心律失常类型，其发病率随年龄增长而升高。本研究采用射频消融装置（RF ablation device）实施经桡入路手术以恢复窦性心律（SR）；针对迷宫手术（Maze surgery）后的窦性心律维持组（n=4）与房颤复发组（n=3），研究人员利用左心耳的福尔马林固定石蜡包埋（FFPE）样本开展了基因芯片差异分析。