Next Generation Sequencing of piRNAs in 3 prostate cancer tissues and 3 paired prostate tissues

iRNAs have been demonstrated to play crucial roles in cancer development by directing the post-transcriptional regulation of target gene expression. We analyzed the expression profile of piRNAs in 3 of the prostate cancer tissues and matched normal adjacent tissues by piRNA sequencing. The aim of this analyse was to find the different expressed piRNAs in prostate cancer. Overall design: Examination of 3 prostate cancer tissues and 3 paired prostate tissues

piRNA（piwi-interacting RNA）已被证实通过介导靶基因表达的转录后调控，在癌症发生发展中发挥关键作用。本研究采用piRNA测序技术，对3例前列腺癌组织及其配对的癌旁正常组织的piRNA表达谱进行了分析，旨在筛选出前列腺癌组织中差异表达的piRNA。实验设计：纳入3例前列腺癌组织与3例配对正常前列腺组织开展检测。