Generation Scotland: Scottish Family Health Study

A collaboration between the Universities of Edinburgh, Glasgow, Dundee and Aberdeen, and NHS Scotland, to provide resources for genetic and medical research.

The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a collection of genetic, medical, family history and lifestyle information from over 24,000 volunteers. It is an intensively phenotyped, family-based cohort for the study of the genetic basis of common complex diseases and response to treatments. The cohort includes just over 24,000 participants recruited 2006-11, with most consenting to record linkage and recontact. Participants gave blood or saliva samples (for processing, biochemistry and cryopreservation) and a urine sample. The blood or saliva samples were processed to DNA and extensive genotyping was carried out on over 20,000 participants by 2015, with DNA methylation assayed on 10,000 by 2019. Follow up is primarily through record linkage and includes linkage to GP records and also via online questionnaires, including CovidLife.y history and lifestyle information from over 24,000 volunteers. it is an intensively phenotyped, family-based cohort for the study of the genetic basis of common complex diseases and response to treatments. The cohort includes just over 24,000 participants recruited 2006-11, with most consenting to record linkage and recontact. Participants gave blood or saliva samples (for processing, biochemistry and cryopreservation) and a urine sample. The blood or saliva samples were processed to DNA and extensive genotyping was carried out on over 20,000 participants by 2015, with DNA methylation assayed on 10,000 by 2019.