Dyslipidemia and Associated Factors among People Living with HIV on Dolutegravir-based Antiretroviral therapy in Central Uganda

This dataset accompanies a cross-sectional study that assessed the prevalence of and factors associated with dyslipidemia among adults living with HIV on dolutegravir (DTG)-based antiretroviral therapy (ART) in central Uganda. The research was guided by the hypothesis that DTG-based ART is associated with a high burden of dyslipidemia, and that specific demographic, clinical, and anthropometric characteristics may influence this risk. The data were collected from 281 systematically sampled adults who had been on DTG-based ART for at least six months, attending care at Kira Health Centre IV in Wakiso District.

The dataset includes information obtained through structured interviewer-administered questionnaires, medical record reviews, anthropometric measurements, and laboratory testing. Variables captured include age, sex, education, ART duration, lifestyle behaviors, comorbidities, viral load, body mass index, waist and hip circumference, and fasting lipid profiles including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides. Data were collected by trained research assistants following standardized procedures, and all laboratory analyses were conducted in certified clinical laboratories.

The study found that 44.1% of participants had dyslipidemia, with low HDL cholesterol being the most common abnormality, affecting 39.9% of the sample. Elevated total cholesterol and LDL cholesterol were less common, affecting 5.7% and 5.0% of participants, respectively. Multivariable logistic regression analysis was used to identify associated factors, and waist circumference demonstrated a moderate ability to predict dyslipidemia with an area under the ROC curve of 0.577 (95% CI: 0.511–0.644).

This dataset provides valuable insight into the metabolic complications associated with modern HIV treatment regimens in sub-Saharan Africa. It highlights the need for routine lipid monitoring and risk assessment among patients on DTG-based ART. The data can be interpreted to explore associations between ART and cardiovascular risk, assess the predictive value of obesity indices, and inform guidelines on the management of non-communicable disease comorbidities in HIV care settings. Researchers, clinicians, and public health practitioners may find this dataset useful for secondary analyses, modeling, or policy development. Ethical approval was obtained, and all participants provided informed consent. The data have been anonymized and prepared for safe public sharing.

本数据集配套一项横断面研究，该研究评估了乌干达中部接受基于多替拉韦（dolutegravir, DTG）抗反转录病毒治疗（antiretroviral therapy, ART）的HIV感染者人群中血脂异常的患病率及其相关影响因素。研究提出的假说为：基于多替拉韦的抗反转录病毒治疗与较高的血脂异常负担相关，且特定的人口统计学、临床及人体测量学特征可能会影响该发病风险。研究数据采集自瓦基索区基拉第四级健康中心就诊的281名经系统抽样招募的成年患者，这些患者均已接受基于多替拉韦的抗反转录病毒治疗至少6个月。

本数据集包含通过结构化访谈式问卷、病历审查、人体测量及实验室检测获取的相关信息。采集的变量包括年龄、性别、受教育程度、抗反转录病毒治疗时长、生活方式行为、合并症、病毒载量、体质量指数、腰围及臀围，以及空腹血脂谱，具体涵盖总胆固醇、高密度脂蛋白（high-density lipoprotein, HDL）、低密度脂蛋白（low-density lipoprotein, LDL）及甘油三酯。数据由经过培训的研究助理按照标准化流程采集，所有实验室分析均在认证临床实验室完成。

研究结果显示，44.1%的参与者存在血脂异常，其中以高密度脂蛋白胆固醇降低最为常见，影响了39.9%的研究样本。总胆固醇升高与低密度脂蛋白胆固醇升高相对少见，分别影响5.7%与5.0%的受试者。研究采用多变量logistic回归分析确定相关影响因素，结果表明腰围具备中等程度的血脂异常预测能力，受试者工作特征曲线（ROC曲线）下面积为0.577（95%置信区间：0.511–0.644）。

本数据集为了解撒哈拉以南非洲地区现代HIV治疗方案相关的代谢并发症提供了宝贵视角，凸显了对接受基于多替拉韦抗反转录病毒治疗的患者开展常规血脂监测与风险评估的必要性。该数据可用于探究抗反转录病毒治疗与心血管风险之间的关联、评估肥胖相关指标的预测价值，并可为HIV诊疗场景下非传染性疾病合并症的管理指南制定提供参考。研究人员、临床医师及公共卫生从业者可将本数据集用于二次分析、建模或政策制定等工作。本研究已获得伦理批准，所有参与者均签署了知情同意书。所有数据均已匿名化处理，可安全公开共享。