Sequence multi-drug resistant Acinetobacter baumannii strains for ARLG-ICMR. Acinetobacter baumannii

As described in the Antibacterial Resistance Leadership Group (ARLG) research plan for neonatal A. baumannii infections in India, strains will be exchanged between ARGL labs and Indian hospitals, facilitated by the Indian Council of Medical Research (ICMR) under the auspices of the Vaccine Action Program (VAP). Initial phenotypic and strain type classification will be performed by the ARLG and approximately 20 DNA samples representing geographic and clinical diversity will be provided to JCVI for sequencing (10 from ARLG and 10 from ICMR). The analysis plan will comprise assembly and annotation, followed by phylogenetic analysis to determine whether the Indian strains represent multiple distinct groups (sporadic infections) or clonal groups that suggest that the strains are endemic in each hospital. Data analysis will be performed in collaboration with ARLG and ICRM scientists.

本数据集依据印度新生儿鲍曼不动杆菌（A. baumannii）感染的抗菌药物耐药性领导小组（Antibacterial Resistance Leadership Group, ARLG）研究计划制定。菌株交换工作将由印度医学研究理事会（Indian Council of Medical Research, ICMR）在疫苗行动计划（Vaccine Action Program, VAP）的统筹支持下开展，负责协调ARLG实验室与印度各家医院之间的菌株流转。ARLG将率先完成菌株的表型鉴定与分型工作，并向JCVI提供约20份覆盖不同地域与临床多样性的DNA样本用于测序，其中10份源自ARLG实验室，剩余10份来自ICMR。数据分析流程将包含基因组组装与注释环节，随后开展系统发育分析，以明确印度分离菌株究竟属于多个独立类群（即散发性感染），还是提示各医院内菌株呈地方流行特征的克隆群。数据分析工作将由ARLG与ICRM的科研人员合作完成。