Transition Metal Free alpha-C-Alkylation of Ketones Using Secondary Alcohols - data

A base-mediated a-C-alkylation of ketones with secondary alcohols has been developed. This transition metal free approach employs KOt-Bu as the base and exhibits a broad scope, allowing a range of commodity aliphatic secondary alcohols and 1-arylethanols to be employed as alkylating agents. Aryl methyl ketones undergo selective mono-a-C-alkylation in high isolated yields (23 examples, 65% average yield).Analysis of reaction products from this methodology resulted in the following data:1H, 19F and 13C NMR raw data filesIR spectraHigh-Resolution Mass Spectrography spectra.本研究开发了一种碱介导的酮与二级醇的α-碳烷基化反应方法。该无过渡金属方法以叔丁醇钾（KOt-Bu）作为碱，底物适用范围广泛，可使用多种商用脂肪族二级醇与1-芳基乙醇作为烷基化试剂。芳基甲基酮可发生选择性单α-碳烷基化反应，且分离产率优异（共23个反应实例，平均产率达65%）。对该方法的反应产物进行分析后，得到以下数据：1H、19F及13C核磁共振波谱（Nuclear Magnetic Resonance, NMR）原始数据文件、红外光谱（Infrared Spectroscopy, IR）谱图以及高分辨质谱（High-Resolution Mass Spectrography, HRMS）谱图。