Escherichia coli strain:R1 Genome sequencing

Pathogenic E. coli strains that carry multiple virulence determinants such as cytotoxic necrotizing factors (CNFs), hemolysins (Hlys), and fimbrial adhesins are responsible for various diseases of humans and animals. These virulence factors are usually encoded by plasmids. E. coli R1, which was isolated from a calf with diarrhea, carry multiple toxin genes including CNF and hemolysins. The interactions between these bacterial toxins produced by E. coli R1 and various mammalian cells are of our research interests.

携带细胞毒性坏死因子（cytotoxic necrotizing factors, CNFs）、溶血素（hemolysins, Hlys）以及菌毛黏附素（fimbrial adhesins）等多种毒力决定簇的致病性大肠杆菌菌株，可引发人类与动物的多种疾病。这类毒力因子通常由质粒（plasmids）编码。从腹泻犊牛中分离得到的大肠杆菌R1，携带有包括CNFs与溶血素在内的多种毒素基因。本研究的关注重点为大肠杆菌R1所产生的这类细菌毒素与多种哺乳动物细胞之间的相互作用。