X-chromosome dosage compensation dynamics in human early embryos. X-chromosome dosage compensation dynamics in human early embryos

Studying X-chromosome dosage compensation dynamics in human early embryos using single cell RNA sequencing Overall design: Here, weuse single-cell RNA-seq to report the X:A ratio and timing of XCI in pre- and peri-implantation human embryos up to fourteen days in culture.

利用单细胞RNA测序（single cell RNA sequencing）研究人类早期胚胎的X染色体剂量补偿（X-chromosome dosage compensation）动态变化
总体实验设计：本研究采用单细胞RNA-seq技术，对体外培养至14天的植入前及围植入期人类胚胎进行分析，解析其X:A（X染色体与常染色体）表达比值与X染色体失活（XCI，X-chromosome inactivation）的发生时序。