Versatile Enantioselective Synthesis of Functionalized Lactones via Copper-Catalyzed Radical Oxyfunctionalization of Alkenes

A versatile method for the rapid synthesis of diverse enantiomerically enriched lactones has been developed based on Cu-catalyzed enantioselective radical oxyfunctionalization of alkenes. The scope of this strategy encompasses a series of enantioselective difunctionalization reactions: oxyazidation, oxysulfonylation, oxyarylation, diacyloxylation, and oxyalkylation. These reactions provide straightforward access to a wide range of useful chiral lactone building blocks containing tetrasubstituted stereogenic centers, which are hard to access traditionally.本研究开发了一种基于铜（Cu）催化烯烃对映选择性自由基氧化官能化反应的通用方法，可快速合成多种对映体富集的内酯。该策略的底物适用范围涵盖一系列对映选择性双官能化反应：氧叠氮化、氧磺酰化、氧芳基化、二酰氧基化以及氧烷基化。此类反应能够便捷地获取多种带有四取代手性中心的手性内酯砌块，而这类砌块通过传统方法较难获得。