The Gene Profiles of Primary and Heterogeneous Metastases of Colorectal Cancer

The incidence and mortality of colorectal cancer in China’s cancer disease spectrum is on the rise, and it is a common malignant tumor that harms the health of Chinese residents.In patients with synchronous metastatic colorectal cancer, RAS status is highly consistent in primary focus and metastasis, so NCCN guidelines recommend RAS testing of primary or metastatic tissue is feasible .However, there are also some reports that the difference of RAS status between primary and metastatic lesions was up to 22%.In additiont,there are few studies on whether the gene profile of the metastatic lesion is the same as that of the primary lesion in patients with postoperative heterogeneous metastasis in patients with stage III colorectal cancer.

在中国癌症疾病谱中，结直肠癌的发病率与死亡率均呈上升趋势，是危害我国居民健康的常见恶性肿瘤。在同步转移性结直肠癌患者中，原发灶与转移灶的RAS状态具有高度一致性，因此美国国家综合癌症网络（National Comprehensive Cancer Network, NCCN）指南推荐，对原发灶或转移组织进行RAS检测具备可行性。但也有部分研究报道称，原发灶与转移灶的RAS状态差异最高可达22%。此外，针对Ⅲ期结直肠癌术后发生异质性转移的患者，其转移灶与原发灶的基因特征是否一致的相关研究尚且较少。