Erratum: Subthalamic Nucleus High-Frequency Stimulation for Advanced Parkinson's Disease: Motor and Neuropsychological Outcome after 10 Years

<b><i>Background:</i></b> Since the introduction of subthalamic nucleus deep brain stimulation (STN DBS), many clinical studies have shown that this therapy is safe and effective in the short and medium term. Only little is known about long-term results. <b><i>Objectives:</i></b> To provide an analysis of motor and cognitive outcome 10 years after STN DBS. <b><i>Methods:</i></b> In this observational cohort study, we report on the motor and cognitive outcome in a cohort of 26 Parkinson's disease patients who were prospectively followed up for 10 years after STN DBS surgery. <b><i>Results:</i></b> In the early post-operative phase, improvement in the Unified Parkinson's Disease Rating Scale (UPDRS) III (10.6, p &lt; 0.01) and IV (2.5, p &lt; 0.01) was seen as well as a 32% reduction in levodopa equivalent dose (p &lt; 0.01). After 5 years, a worsening of the motor performance was observed. The worsening of motor performance was mainly due to a deterioration in bradykinesia (12.4 ± 4.6, p &lt; 0.05) and axial symptoms (6.9 ± 2.8, p &lt; 0.01). Memory function seemed to improve in the short term, but there was a significant decline between 1 and 5 years after surgery (p &lt; 0.01). Mood remained relatively stable during follow-up, and one third of the patients showed impulsive behaviour after surgery. <b><i>Conclusions:</i></b> The motor performance of patients showed deterioration over time, due to an increase in bradykinesia and axial symptoms.

**背景**：自丘脑底核脑深部刺激（subthalamic nucleus deep brain stimulation，STN DBS）技术应用于临床以来，多项临床研究已证实该疗法在短期与中期治疗中安全有效，但目前关于其长期疗效的认知仍较为有限。
**研究目的**：旨在分析丘脑底核脑深部刺激术后10年的运动与认知转归情况。
**研究方法**：本项观察性队列研究纳入26例帕金森病（Parkinson's disease）患者，所有患者均接受丘脑底核脑深部刺激手术，并被前瞻性随访10年，本研究报告该队列患者的运动与认知转归结果。
**研究结果**：术后早期，患者统一帕金森病评定量表（Unified Parkinson's Disease Rating Scale, UPDRS）Ⅲ项（评分变化10.6，p<0.01）与Ⅳ项（评分变化2.5，p<0.01）均得到显著改善，左旋多巴等效剂量（levodopa equivalent dose）降低32%（p<0.01）。术后5年时，患者运动功能出现恶化，该恶化主要源于运动迟缓（bradykinesia，12.4±4.6，p<0.05）与轴性症状（axial symptoms，6.9±2.8，p<0.01）的加重。记忆功能在短期似乎有所改善，但术后1~5年期间出现显著下降（p<0.01）。随访期间患者情绪相对稳定，且有三分之一的患者术后出现冲动行为。
**研究结论**：患者的运动功能随时间推移逐渐恶化，这主要由运动迟缓与轴性症状的加重所导致。