Factors associated with spontaneous abortion: a systematic review

Abstract Objectives: to compile studies produced regardinggenetic and non-genetic risks factors associated with occurrence of spontaneous abortion. Methods: it talks about a systematic review article, with studies between January of 2008 to November of 2018 according to SciELO, PubMed, Lilacs and BVS. Results: in total, 567 articles were found. After applying the definedeligibility criteria, 44 articles made part of the review, being the majority published on Asia between 2008 and 2011, and 10 articles published on Brazil. Not genetic causes like sociodemographic factors and healthy state were among the most associated conditions of spontaneous abortion. Asiatic continent had predominance about the correlation of spontaneous abortion with factors related to life style like obesity, smoking and labor activities, on the other hand, in the Americas, causes related to sociodemographics factors like low pay and low studies are high-lighted. Conclusions: the risk factors change about the occurrence region, being important to make local studies capable of subsidize the implantation of public politics and to reduce abortions.

摘要 研究目的：本研究旨在汇编与自然流产（spontaneous abortion）发生相关的遗传与非遗传风险因素的已有研究成果。方法：本研究为一篇系统综述，检索范围覆盖2008年1月至2018年11月期间发表于SciELO、PubMed、Lilacs及BVS数据库的相关文献。结果：本次检索共获取567篇文献，经预设入选排除标准筛选后，最终有44篇文献纳入本次综述。其中绝大多数文献发表于2008至2011年的亚洲地区，另有10篇文献来自巴西。社会人口学特征与健康状态等非遗传病因，是与自然流产关联最为密切的因素。在亚洲地区，自然流产与肥胖、吸烟、职业活动等生活方式相关因素的相关性研究占主导地位；而在美洲地区，低收入、受教育水平偏低等社会人口学相关病因则更为突出。结论：自然流产的风险因素因地域而异，开展本土化研究可为公共政策的落地实施提供依据，助力降低流产发生率。