Human SOD1 overexpressed in glial cells accelerates fly death by BMAA.

Shown are survival rates of 35 day-old male sod1 transgenic flies under 3 mM BMAA treatment. Panels A, B, and C represent flies expressing mutant human A4V, G85R, and wild type SOD1 proteins, respectively. Like 5 day-old time points (Figure 3, A-C), the SOD1 flies survived longer compared to the controls (CS and dSOD1). The 50% survival rate is increased by 10, 30 and 30% for A4V, G85R, wt SOD1, respectively, when compared to dSOD1 flies. Differences were considered statistically significant if p

本数据集展示了经3 mM β-甲氨基-L-丙氨酸（BMAA）处理的35日龄雄性超氧化物歧化酶1（SOD1）转基因果蝇的存活率。其中A、B、C三个面板分别对应表达突变型人源A4V、G85R及野生型SOD1蛋白的果蝇。与5日龄时间点的实验结果（图3A-C）一致，表达SOD1的果蝇存活率均高于对照组（CS果蝇与dSOD1果蝇）。相较于dSOD1果蝇，A4V、G85R及野生型SOD1组的50%存活率分别提升了10%、30%与30%。当p值满足统计学显著性判定标准时（原文此处未完整显示），组间差异被认为具有统计学意义。