Gene expression profile at single cell level of mice infected with Mtb (-/+ TLR2). Gene expression profile at single cell level of mice infected with Mtb (-/+ TLR2)

The lung is a key site of Mtb infection. We profiled the lung ecosystem of mice following Mtb infection. Overall design: Murine lungs (-/+ TLR2) were infected with H37Rv Mtb and profiled by 10X genomics,

肺是结核分枝杆菌（Mycobacterium tuberculosis, Mtb）感染的关键靶器官。本研究对结核分枝杆菌感染后的小鼠肺部生态系统开展了表征分析。总体实验设计：将携带或不携带Toll样受体2（Toll-like receptor 2, TLR2）的小鼠肺部感染H37Rv型结核分枝杆菌，并通过10×基因组学（10X Genomics）完成测序表征。