Compounds that inhibit SFV replication in the SFV-Rluc screening assay.

aIC50 values for SFV replication were determined using SFV-Rluc infection (MOI 0.001 in BHK cells and detection at 14 h post-infection).bCell viability IC50 values were determined by ATP assay after 48 h exposure of BHK cells.cSelectivity indices (SI) were calculated as the ratio of the two values. All results represent the mean values of two individual experiments both run in triplicate (CV ranged from 8.1 to 21.3% in the SFV-Rluc experiments). NC = natural compounds, PC = pharmaceutical compounds.a. 测定SFV复制的半数抑制浓度（half maximal inhibitory concentration, IC50）采用SFV-Rluc感染实验：以感染复数（multiplicity of infection, MOI）0.001感染BHK细胞，并于感染后14小时完成检测。 b. BHK细胞经受试物暴露48小时后，采用ATP检测法测定其细胞活力半数抑制浓度（IC50）。 c. 选择性指数（selectivity indices, SI）按上述两项检测值的比值计算得到。 所有结果均为两次独立重复实验的平均值，每次实验均设置3个复孔；SFV-Rluc实验的变异系数（coefficient of variation, CV）介于8.1%至21.3%之间。其中NC代表天然化合物（natural compounds），PC代表药用化合物（pharmaceutical compounds）。