Altering the insertional specificity of a Drosophila transposable element.
收藏PubMed Central1992-03-01 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC48565/
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资源简介：
Vectors derived from the Drosophila P element transposon are widely used to make transgenic Drosophila. Insertion of most P-element-derived vectors is nonrandom, but they exhibit a broad specificity of target sites. During experiments to identify cis-acting regulatory elements of the Drosophila segmentation gene engrailed, we identified a fragment of engrailed DNA that, when included within a P-element vector, strikingly alters the specificity of target sites. P-element vectors that contain this fragment of engrailed regulatory DNA insert at a high frequency near genes expressed in stripes. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1992-03-01
