FInnish National Protein Crystallography Consortium

The Finnish BAG encompasses 24 groups active in crystallography in Finland. The projects vary widely and include membrane proteins and protein complexes, other proteins involved in disease and antibiotics and drug development and discovery (endoplasmic regulation and protein secretion, ADP-ribosylation and several oncogenic proteins including kinases, biocatalysis) and several pathogen proteins and various enzyme targets and e.g. studies on phytochrome photoreceptors and complexes involved in actin dynamics regulation. Overall the BAG serves the national needs for highly variable projects, with different biological and biotechnological applications. Several project will benefit from microfocus beam lines and tunable wavelength options for phasing, others benefit from quick robust screening by MASSIF. Biology lab is needed for SAXS experiments.

芬兰BAG汇集了芬兰国内24个从事晶体学研究的课题组。该数据集涵盖的研究项目覆盖领域广泛，涉及膜蛋白与蛋白质复合物、疾病相关的其他蛋白质，以及抗生素与药物研发及发现领域（包括内质网调控与蛋白质分泌、ADP核糖基化、包括激酶在内的多种致癌蛋白、生物催化），还涵盖多种病原蛋白、各类酶靶点，例如针对光敏色素光受体以及参与肌动蛋白动态调控的复合物的研究。总体而言，该BAG可满足国内对多样化研究项目的需求，相关项目覆盖不同的生物学与生物技术应用场景。部分研究项目可借助微聚焦光束线与用于相位解析的可调波长选项开展实验，其余项目则可通过MASSIF实现快速可靠的筛选。开展小角X射线散射（Small Angle X-ray Scattering, SAXS）实验需依托生物学实验室。