Liver transcriptome profiling of liver specific miR-122 knockout and control male mice

Liver transcriptome profiling of liver specific miR-122 knockout (miR-122loxP/loxP Alb-Cre) and control (miR-122loxP/loxP) male mice. Expression profile of several hundred mRNAs that include miR-122 targets were altered in miR-122 KO livers. Loss of miR-122 in the germ line resulted in significant changes in hepatic gene expression profile. Among the upregulated genes many are direct targets of miR-122 GSM517838-GSM517847: Liver transcriptome profiling of liver specific miR-122 knockout and control male mice. Total liver RNA from 8 week old five control and five liver-specific miR-122 knock out male mice (C57/BL6J background) GSM791601-GSM791604: Liver transcriptome profiling of germ-line miR-122 knockout and control male mice. Liver RNA from 5 week old control (floxed) and miR-122KO mice were analyzed by mouse whole transcriptome profiling.

本数据集包含肝脏特异性miR-122（microRNA-122）敲除（miR-122loxP/loxP Alb-Cre）雄性小鼠与对照（miR-122loxP/loxP）雄性小鼠的肝脏转录组谱分析数据。
在miR-122敲除的肝脏组织中，包含miR-122靶标的数百种mRNA的表达谱发生了显著改变。
生殖系miR-122缺失会显著改变肝脏基因的表达谱。
在上调基因中，多数为miR-122的直接靶标。
GSM517838-GSM517847：肝脏特异性miR-122敲除与对照雄性小鼠的肝脏转录组谱分析。实验样本为8周龄的5只对照雄性小鼠与5只肝脏特异性miR-122敲除雄性小鼠（C57/BL6J遗传背景）的总肝脏RNA。
GSM791601-GSM791604：生殖系miR-122敲除与对照雄性小鼠的肝脏转录组谱分析。采用小鼠全转录组谱分析技术，对5周龄对照（floxed，两侧携带loxP位点的个体）与miR-122敲除小鼠的肝脏RNA进行检测分析。