Asymmetric Allylic C–H Alkylation of Allyl Ethers with 2‑Acylimidazoles

An asymmetric allylic C–H alkylation of allyl ethers has been established by chiral phosphoramidite-palladium catalysis, affording a wide variety of functionalized chiral 2-acylimidazoles in moderate to high yields and with high levels of enantioselectivity. Moreover, this protocol could be applied to a concise asymmetric synthesis of a tachykinin receptor antagonist.本工作开发了手性亚磷酰胺-钯催化的烯丙基醚不对称烯丙基C-H烷基化反应，能够以中等至优异的产率与极高的对映选择性，获得多种官能化的手性2-酰基咪唑类化合物。此外，该合成策略可应用于速激肽受体拮抗剂的简洁不对称合成。