*The preferred adverse event term used for “CF exacerbation” was “cystic fibrosis.”A patient may have been counted in more than one preferred term. Percentages were calculated using the total number o
Tankyrases are multifunctional poly(adenosine diphosphate-ribose) polymerases that regulate diverse biological processes including telomere maintenance and cellular signaling. These processes are oft
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, encoding for a chloride ion channel. Membrane expression of CFTR is negatively regul