A health metadata-based management approach for comparative analysis of high-throughput genetic sequences for quantifying antimicrobial resistance reduction in Canadian hog barns (Fecal-piglet3)

we describe a comprehensive investigative methodology comparing the effect of the adoption of the RWA approach with non-RWA pig production operations where antibiotics may still be administered on animals as needed. Our experimental approach involves a multi-year longitudinal investigation of pig farming to determine the effects of antibiotic usage on the prevalence of antimicrobial resistance (AMR) and pathogen abundance in the context of the drug exposures recorded in the RWA versus non-RWA scenarios

本研究阐述了一套全面的调查方法，用于对比采用RWA（RWA）养殖模式的生猪生产与仍可根据生猪个体需求施用抗生素的非RWA养殖模式生猪生产的应用效果。本实验方案开展了多年期生猪养殖纵向调查，旨在结合RWA与非RWA场景下记录的药物暴露数据，明确抗生素使用对抗微生物耐药性（antimicrobial resistance, AMR）流行率及病原体丰度的影响。