Effects of magnesium sulfate and dioctyl sodium sulfosuccinate on fecal hydration, output and systemic hydration in healthy horses

ABSTRACT Magnesium sulphate (MS) and dioctyl sodium sulphosuccinate (DSS) are laxative drugs frequently used for the treatment of impactions. The aim of this study was to compare the effects of MS and DSS in fecal hydration, output and systemic hydration in healthy horses. Five healthy horses received 3 treatments with a 21-day interval. Treatment 1 was performed with administration of 4 liters of warm water; treatment 2: administration of 4 liters of warm water associated with 1g/kg of MS; and treatment 3: administration of 4 liters of warm water associated with 20mg/kg DSS. General and specific physical examination of the digestive system were performed, alongside with packed cell volume and total plasma protein measurement, abdominal ultrasonography and quantification of the amount and hydration of feces, before and 6, 12, 24, 36 and 48 hours after the treatments. No adverse effects were observed. The administration of laxatives promoted greater fecal output and hydration without resulting in systemic dehydration, yet no differences were observed between treatments. The absence of adverse effects of DSS demonstrates the safety of its use as a laxative drug at a dose of 20mg/kg. Studies comparing the effects of the laxative drugs in horses with large colon impaction are needed.

摘要：硫酸镁（Magnesium sulphate, MS）与多库酯钠（dioctyl sodium sulphosuccinate, DSS）是临床常用于治疗粪便嵌塞的泻药。本研究旨在对比MS与DSS对健康马匹粪便水化状态、粪便排出量及全身水化状态的影响。5匹健康实验马接受3种处理方案，各处理间隔21天。处理1为灌服4升温水；处理2为灌服4升温水联合1g/kg的硫酸镁；处理3为灌服4升温水联合20mg/kg的多库酯钠。分别在处理前及处理后6、12、24、36、48小时，对马匹进行消化系统的一般体格检查与专项检查，同时检测红细胞压积与血浆总蛋白水平、开展腹部超声检查，并对粪便量与粪便水化程度进行定量检测。本研究未观察到任何不良反应。给予泻药可提升粪便排出量与粪便水化程度，且未引发全身脱水，但两种泻药的处理组间未发现显著差异。多库酯钠无不良反应的结果证明，其以20mg/kg剂量作为泻药使用时具有良好安全性。未来仍需开展对比泻药对大肠粪便嵌塞马匹作用效果的相关研究。