Pseudouridine in small RNAs. Pseudouridine in small RNAs

Pseudouridine is an isomer of uridine and is the most common RNA modification in both procaryotes and eucaryotes. It is found in ribosomal, transfer, and other structural RNA as well as in some mRNA and non-coding RNA. We have found abundant pseudouridine in small RNA and their precursors in Arabidopsis. Overall design: Identification of pseudouridylated small RNAs and their precursors in Arabidopsis thaliana

假尿苷（pseudouridine）是尿苷的同分异构体，亦是原核生物与真核生物中最为常见的RNA修饰形式。其广泛分布于核糖体RNA、转运RNA及其他结构RNA中，同时也存在于部分信使RNA（mRNA）与非编码RNA（non-coding RNA）内。我们在拟南芥（Arabidopsis）的小RNA及其前体中发现了丰富的假尿苷。实验整体设计：鉴定拟南芥中发生假尿苷修饰的小RNA及其前体。