Table_1_Evaluation of the Effects on Uninfected Pregnant Women and Their Pregnancy Outcomes During the COVID-19 Pandemic in Beijing, China.docx

BackgroundPeople's lifestyles may have changed during the COVID-19 pandemic, which may have a profound impact on pregnant women and newborns. This study aims to assess the effects of the COVID-19 pandemic on uninfected pregnant women and their newborns, including potential environmental factors.
MethodsWe retrospectively analyzed the pregnancy complications of 802 cases in the pandemic group and 802 controls in the pre-pandemic group in a matched nested case-control study, and evaluated the association with sociodemographic features, lifestyles, and other factors in 311 pregnant women with adverse pregnancy outcomes.
ResultsCompared to the pre-pandemic group, the rates of anemia, vaginitis, shoulder dystocia, and adverse pregnancy outcomes such as preterm birth were increased in the pandemic group. After controlling for the covariates, we observed a higher risk of adverse pregnancy outcomes in the pandemic group. Pregnant women with adverse pregnancy outcomes had an increased rate of anemia and vaginal candidiasis.
ConclusionCOVID-19 pandemic has profound effects on adverse pregnancy outcomes, suggesting the importance of ensuring regular prenatal checkups and keeping a healthy lifestyle.

背景 新型冠状病毒肺炎（COVID-19）疫情期间，民众的生活方式或发生改变，这可能对孕妇及新生儿造成深远影响。本研究旨在评估COVID-19疫情对未感染孕妇及其新生儿的影响，涵盖潜在环境因素。
方法 本研究采用匹配巢式病例对照研究设计，回顾性分析疫情组802例病例与疫情前组802例对照的妊娠并发症情况，并针对311例发生不良妊娠结局的孕妇，评估其不良妊娠结局与社会人口学特征、生活方式及其他相关因素的关联。
结果 与疫情前组相比，疫情组孕妇的贫血、阴道炎、肩难产及早产等不良妊娠结局的发生率均有所升高。在校正协变量后，观察到疫情组孕妇发生不良妊娠结局的风险更高。发生不良妊娠结局的孕妇，其贫血与阴道念珠菌病（vaginal candidiasis）的发生率亦有所上升。
结论 COVID-19疫情对不良妊娠结局存在深远影响，这提示保障规律产前检查与维持健康生活方式的重要性。