Time-Course of Changes in Inflammatory Response after Whole-Body Cryotherapy Multi Exposures following Severe Exercise

The objectives of the present investigation was to analyze the effect of two different recovery modalities on classical markers of exercise-induced muscle damage (EIMD) and inflammation obtained after a simulated trail running race. Endurance trained males (n = 11) completed two experimental trials separated by 1 month in a randomized crossover design; one trial involved passive recovery (PAS), the other a specific whole body cryotherapy (WBC) for 96 h post-exercise (repeated each day). For each trial, subjects performed a 48 min running treadmill exercise followed by PAS or WBC. The Interleukin (IL) -1 (IL-1), IL-6, IL-10, tumor necrosis factor alpha (TNF-α), protein C-reactive (CRP) and white blood cells count were measured at rest, immediately post-exercise, and at 24, 48, 72, 96 h in post-exercise recovery. A significant time effect was observed to characterize an inflammatory state (Pre vs. Post) following the exercise bout in all conditions (p本研究旨在分析两种不同恢复手段对模拟越野跑比赛后产生的运动诱导肌肉损伤（exercise-induced muscle damage, EIMD）与炎症经典标志物的影响。招募11名经过耐力训练的男性受试者，采用随机交叉设计开展两项间隔1个月的实验：其中一项实验采用被动恢复（passive recovery, PAS），另一项则在运动后96小时内每日实施全身冷疗（whole body cryotherapy, WBC）。每项实验中，受试者先在跑步机上完成48分钟跑步训练，随后分别实施被动恢复或全身冷疗。分别在静息状态、运动即刻以及运动后恢复阶段的24、48、72、96小时，检测受试者的白细胞介素（Interleukin, IL）-1（IL-1）、IL-6、IL-10、肿瘤坏死因子-α（tumor necrosis factor alpha, TNF-α）、C反应蛋白（C-reactive protein, CRP）以及白细胞计数。所有实验条件下，运动后炎症状态（赛前与赛后）均呈现出显著的时间效应（p