HPV-positive SiHa cells expressing antitumor intrabodies targeting E6 and E7 oncoproteins

I7NUC and 43M2SD are recombinant antibodies in single-chain format (scFvs) specific for the E6 and E7 oncoproteins of the high oncogenic risk HPV16 genotype. Here, we performed RNA-seq analysis of HPV16-positive SiHa cells expressing I7NUC and 43M2SD.

I7NUC与43M2SD为针对高致癌风险HPV16基因型E6及E7癌蛋白的单链可变片段（single-chain variable fragments，scFvs）格式重组抗体。本研究对表达I7NUC与43M2SD的HPV16阳性SiHa细胞开展了RNA测序（RNA-seq）分析。