Count matrix and meta-data table [Hypertension T cells, icell8]

Adaptive immune response mediated by T cells plays a vital role in the initiation and maintenance of blood pressure (BP). Memory T cells, antigen-specific T cells, could response specific towards repeated hypertensive stimuli. Though the roles of memory T cells in animal models are well studied, the maintainance and functions of them in hypertensive patients are poorly understood. Here, we focused on the circulating memory T cells of hypertensive patients. By using single cell RNA sequencing technology, subsets of memory T cells were identified. DEGs and functional pathways were explored for the related biological function in each memory T populations. Our data suggest CD8 TEMs as well as the marker genes could be preventive targets for patients with hypertensive cardiovascular disease. <br> Dataset description: This dataset covers five hypertension samples (H1-H5) and five normal samples (N1-N5). It contains two files: 1. scmatrix.tsv.gz: count matrix of all cells. 2. scmetadata10.txt.gz: Meta-data annotation of each cell. <br>T细胞介导的适应性免疫应答（adaptive immune response）在血压（blood pressure，BP）的起始与维持过程中发挥关键作用。记忆T细胞作为抗原特异性T细胞，可对重复性高血压刺激产生特异性免疫应答。尽管记忆T细胞在动物模型中的作用已被广泛研究，但其在高血压患者体内的维持机制与功能却鲜为人知。本研究聚焦于高血压患者的循环记忆T细胞，借助单细胞RNA测序（single-cell RNA sequencing）技术鉴定出了记忆T细胞的多个亚群，并针对各记忆T细胞亚群的相关生物学功能，对其差异表达基因（differentially expressed genes，DEGs）及功能通路展开了探究。本研究数据显示，CD8阳性效应记忆T细胞（CD8 TEMs）及其标记基因可作为高血压性心血管疾病患者的预防性治疗靶点。 数据集说明：本数据集涵盖5例高血压样本（H1-H5）及5例正常对照样本（N1-N5），包含两个文件：1. scmatrix.tsv.gz：所有细胞的计数矩阵；2. scmetadata10.txt.gz：单个细胞的元数据注释文件。