Average statistical power of simulated case-control scores in African Americans computed using (a) typed or (b) imputed genotypes.

For each score we list the proportion of SNPs for which the score attains genome-wide significance (defined as P0.4), for R = 1.2, R = 1.5, R = 2.0 simulations (see main text). For R = 1.0 the power is 0 for all scores. In general the MIX score shows an increase in statistical power relative to the ATT score, and a further increase in power relative to the SNP1 score, which is analogous to disease mapping in European or African populations. ATT-dose denotes ATT test using imputation dosages.针对每种评分，我们列出了R=1.2、R=1.5、R=2.0模拟场景下（详见正文），该评分达到全基因组显著性（定义为P0.4）的单核苷酸多态性（Single Nucleotide Polymorphisms，SNPs）占比。当R=1.0时，所有评分的统计功效均为0。总体而言，MIX评分的统计功效优于ATT评分，且相较于SNP1评分进一步提升；SNP1评分的应用场景与欧洲或非洲人群的疾病图谱绘制相仿。ATT-dose指采用基因型填充剂量开展的ATT检验。