Table 1_Temperature-responsive hydrogel of oclacitinib maleate administered via the rectum in rabbit.docx

BackgroundThe extensive and intense itching caused by skin diseases can significantly diminish the quality of life for companion animals. Oral administration of oclacitinib maleate is recognized as an important treatment for alleviating itching. Oral medications are affected by the animal’s temperament and swallowing ability.
MethodsIn this study, we developed a temperature-responsive hydrogel containing oclacitinib maleate for rectal administration, and we evaluated its therapeutic potential for treating itching through pharmacokinetic analysis using rabbits as test subjects.
ResultsPharmacokinetic results indicated that the transrectal administration of OM T-R Hydrogel effectively increased the blood concentration of oclacitinib maleate (Tmax = 87 min, Cmax = 37 ng/mL, t1/2λz = 762 min). Furthermore, the OM T-R Hydrogel demonstrated no rectal mucosal irritation, confirming its safety for clinical use.
ConclusionIn conclusion, this paper successfully investigated a promising novel drug delivery system to alleviate pruritus in dogs and cats.

### 研究背景
皮肤疾病引发的剧烈广泛性瘙痒，会显著降低伴侣动物的生活质量。马来酸奥拉替尼（oclacitinib maleate）口服给药是公认的缓解瘙痒的重要治疗手段，但口服给药效果会受动物性情与吞咽能力的影响。

### 研究方法
本研究开发了一种负载马来酸奥拉替尼的温敏水凝胶（temperature-responsive hydrogel）用于直肠给药，并以家兔为实验对象，通过药代动力学分析评估其治疗瘙痒的潜力。

### 研究结果
药代动力学结果显示，经直肠给药的OM T-R温敏水凝胶可有效提升马来酸奥拉替尼的血药浓度（达峰时间Tmax=87 min，峰浓度Cmax=37 ng/mL，消除半衰期t₁/₂λz=762 min）。此外，该OM T-R温敏水凝胶未表现出直肠黏膜刺激性，证实其具备临床应用安全性。

### 研究结论
综上，本研究成功开发了一种极具应用前景的新型给药系统，可用于缓解犬与猫的瘙痒症状。