MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists

This study aims to compare the gene expression profile between wild-type EMT6 cells with those subjected to MTAP knockout, PRMT5 shRNA knockdown, or PRMT5 inhibitor (EPZ015938, EPZ015666) treatment.本研究旨在比较野生型EMT6细胞与经MTAP基因敲除、PRMT5短发夹RNA（short hairpin RNA，shRNA）敲低，或PRMT5抑制剂（EPZ015938、EPZ015666）处理的细胞的基因表达谱。