DataSheet1_Effect of type 2 diabetes on biochemical markers of bone metabolism: a meta-analysis.XLSX

ObjectiveThis meta-analysis aims to examine differences in biochemical markers of bone metabolism between individuals with type 2 diabetes (T2DM) and non-T2DM control groups.
Materials and methodsTwo independent evaluators searched five databases: PubMed, EMBASE, EBSCOhost, Web of Science, and the Cochrane Library. We aimed to identify observational studies investigating the impact of T2DM on biochemical markers of bone metabolism. Literature retrieval covered the period from the establishment of the databases up to November 2022. Studies were included if they assessed differences in biochemical markers of bone metabolism between T2DM patients and non-T2DM control groups using cross-sectional, cohort, or case-control study designs.
ResultsFourteen studies were included in the analysis, comprising 12 cross-sectional studies and 2 cohort studies. Compared to the non-T2DM control group, T2DM patients showed reduced levels of Osteocalcin and P1NP, which are markers of bone formation. Conversely, levels of Alkaline phosphatase and Bone-specific alkaline phosphatase, other bone formation markers, increased. The bone resorption marker CTX showed decreased levels, while TRACP showed no significant difference.
ConclusionIn individuals with T2DM, most bone turnover markers indicated a reduced rate of bone turnover. This reduction can lead to increased bone fragility despite higher bone mineral density, potentially increasing the risk of osteoporosis.
Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php? identifier CRD42022366430.

目的：本项Meta分析（Meta-analysis）旨在探讨2型糖尿病（T2DM）患者与非2型糖尿病对照组之间骨代谢生化标志物的差异。
材料与方法：两名独立评价员检索了PubMed、EMBASE、EBSCOhost、Web of Science及Cochrane图书馆五个数据库，以识别探讨2型糖尿病对骨代谢生化标志物影响的观察性研究。文献检索时限覆盖各数据库建库至2022年11月。纳入研究需采用横断面、队列或病例对照研究设计，评估2型糖尿病患者与非2型糖尿病对照组的骨代谢生化标志物差异。
结果：本分析共纳入14项研究，其中12项为横断面研究，2项为队列研究。与非T2DM对照组相比，2型糖尿病患者的骨形成标志物骨钙素（Osteocalcin）与P1NP水平降低；而另一类骨形成标志物碱性磷酸酶（Alkaline phosphatase）及骨特异性碱性磷酸酶（Bone-specific alkaline phosphatase）水平则升高。骨吸收标志物CTX水平降低，而抗酒石酸酸性磷酸酶（TRACP）无显著差异。
结论：2型糖尿病患者的多数骨转换标志物提示骨转换速率降低。尽管此类患者骨密度可能升高，但骨转换速率降低可引发骨脆性增加，进而可能提升骨质疏松症的发病风险。
系统评价注册信息：https://www.crd.york.ac.uk/prospero/display_record.php?identifier=CRD42022366430