Epigenome analysis of uterin and ovarian carcinosarcoma tissues. Epigenome analysis of uterin and ovarian carcinosarcoma tissues

We performed genome-wide DNA methylation profiling of uterin and ovarian carcinosarcoma tissues derived from patients in the Cancer Institute Hospital of Japanese Foundation for Cancer Research. Overall design: DNA methylation status was analyzed using genomic DNA from each tumor on the Illumina Infinium HumanMethylation 450 BeadChip Arrays (n = 98) or MethylationEPIC BeadChip Arrays (n = 10), according to the manufacturer’s instructions.

本研究针对日本癌症研究基金会癌症研究所医院患者来源的子宫及卵巢癌肉瘤组织开展全基因组DNA甲基化谱分析。整体实验设计：依照制造商操作说明，采用每例肿瘤组织的基因组DNA，通过Illumina Infinium HumanMethylation 450 微珠芯片阵列（n=98）或MethylationEPIC 微珠芯片阵列（n=10）分析DNA甲基化状态。