Hazard ratios (95% confidence intervals) for incident chronic kidney disease by serum bilirubin quartiles among subjects who did not have any evidence of liver disease (N = 10,348).

Model 1: Adjusted for age, smoking, alcohol intake and exercise.
Model 2: Further adjusted for eGFR, CRP, AST, ALT, GGT and metabolic syndrome traits (high glucose, high blood pressure, low HDL cholesterol, high triglycerides and high BMI). *estimated from pooled logistic regression models with serum bilirubin quartiles as time-dependent categorical variable s adjusted for other covariates (age, smoking, alcohol intake, exercise, eGFR, CRP, AST, ALT, GGT and each metabolic syndrome trait) over time as time-dependent variables.
Abbreviations: CI, confidence interval; eGFR: estimated glomerular filtration rate; HDL, high-density lipoprotein; HR, hazard ratio; LDL, low-density lipoprotein; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma-glutamyltransferase.

模型1：校正了年龄、吸烟、饮酒摄入与运动状态。
模型2：进一步校正了估算肾小球滤过率（estimated glomerular filtration rate, eGFR）、C反应蛋白（C-reactive protein, CRP）、天冬氨酸氨基转移酶（aspartate aminotransferase, AST）、丙氨酸氨基转移酶（alanine aminotransferase, ALT）、γ-谷氨酰转移酶（gamma-glutamyltransferase, GGT）以及代谢综合征相关表型（高血糖、高血压、高密度脂蛋白胆固醇降低、高甘油三酯血症与高体质量指数）。*本结果基于合并logistic回归模型估算所得，以血清胆红素四分位数作为时依性分类变量，并针对其他协变量（年龄、吸烟、饮酒、运动、eGFR、CRP、AST、ALT、GGT及各项代谢综合征表型）进行校正，同时将时间作为时依性变量纳入分析。
缩写说明：CI，置信区间（confidence interval）；eGFR：估算肾小球滤过率；HDL，高密度脂蛋白（high-density lipoprotein）；HR，风险比（hazard ratio）；LDL，低密度脂蛋白（low-density lipoprotein）；ALT：丙氨酸氨基转移酶；AST：天冬氨酸氨基转移酶；GGT：γ-谷氨酰转移酶。