Table 1_Marital status and risk of type 2 diabetes among middle-aged and elderly population: a systematic review and meta-analysis.docx

BackgroundMarital status is among the factors influencing type 2 diabetes mellitus (T2DM). However, the precise relationship remains incompletely understood. This meta-analysis aims to evaluate the association between marital status and the incidence of T2DM.
MethodsA review and meta-analysis of observational studies were conducted to investigate the relationship between marital status and diabetes incidence. We searched three databases, including PubMed, Google Scholar, and Scopus, for relevant studies published up to August 16th, 2023. In our initial search, we identified a total of 358 articles. After a demanding screening process involving evaluating titles, abstracts, and full-text content, we ultimately included six studies for our meta-analysis.
ResultComprising a total of 1,440,904 participants, our study found that in comparison to married individuals, unmarried participants exhibited a higher likelihood of developing diabetes [odds ratio (OR): 1.47, 95% confidence interval (CI): 0.88–2.45, I2: 91%, p-value = 0.14]. Divorced participants had a reduced likelihood of developing diabetes compared to married participants (OR: 0.84, 95% CI: 0.77–0.91, I2: 17%, p < 0.001). Similarly, widowed participants showed a lower risk of developing diabetes compared to divorced participants (OR: 0.35, 95% CI: 0.26–0.46, I2: 83%, p < 0.00001).
ConclusionThis study provides strong evidence of links between marital status and type 2 diabetes risk. Unmarried individuals are more susceptible to T2DM, divorced individuals have a lower risk, and widowed individuals exhibit reduced T2DM risk. Further research should investigate underlying mechanisms and confounding factors.

背景：婚姻状况是影响2型糖尿病（type 2 diabetes mellitus, T2DM）的因素之一，但其确切关联尚未完全阐明。本荟萃分析旨在评估婚姻状况与2型糖尿病发病风险之间的关联。
方法：本研究对观察性研究开展系统回顾与荟萃分析，以探讨婚姻状况与糖尿病发病的关联。我们检索了PubMed、Google Scholar、Scopus三个数据库，检索时限截至2023年8月16日。初步检索共获得358篇文献，经严格的标题、摘要及全文筛查流程后，最终纳入6项研究用于本荟萃分析。
结果：本研究共纳入1440904名参与者，结果显示，与已婚人群相比，未婚人群罹患糖尿病的风险更高[比值比（odds ratio, OR）=1.47，95%置信区间（confidence interval, CI）：0.88~2.45，I²=91%，P=0.14]。与已婚人群相比，离异人群的糖尿病发病风险降低（OR=0.84，95%CI：0.77~0.91，I²=17%，P<0.001）。与离异人群相比，丧偶人群的糖尿病发病风险更低（OR=0.35，95%CI：0.26~0.46，I²=83%，P<0.00001）。
结论：本研究为婚姻状况与2型糖尿病发病风险之间的关联提供了强有力的证据。未婚人群更易罹患2型糖尿病，离异及丧偶人群的2型糖尿病发病风险显著降低。未来研究应进一步探讨其潜在机制及混杂因素。