Spatial vulnerabilities of the Escherichia coli genome to spontaneous mutations revealed with improved duplex sequencing

Figure S1. Comparison of MAE and MSE strategies. <br>Figure S2. Family size and error rate across all samples. <br>Figure S3. Features of spontaneous mutations.<br>Figure S4. Signatures of mutation context.<br>Figure S5. The spectra and fraction of mutations.<br>Figure S6. The correlation between mutation and gene expression of E3C.<br>Table S1. Summary of data sources for error rate calculation and the 15 E.coli samples sequenced in this study. <br>Table S2. The error rate of the 15 Tp53 duplex sequencing datasets across 12 error types.<br>Table S3. The mutations we obtained in the 15 samples.<br>Table S4 Summary of hotspot across 15 samples.<br>

图S1. 平均绝对误差（Mean Absolute Error, MAE）与均方误差（Mean Squared Error, MSE）策略对比<br>图S2. 所有样本中的家族规模与错误率<br>图S3. 自发突变特征<br>图S4. 突变背景特征<br>图S5. 突变谱与突变占比<br>图S6. E3C的突变与基因表达相关性<br>表S1. 本研究中测序的15个大肠杆菌（E. coli）样本及误差率计算所用数据来源汇总<br>表S2. 15个Tp53双链测序数据集在12种错误类型下的错误率<br>表S3. 15个样本中获取的突变集合<br>表S4. 15个样本的突变热点汇总