Data Sheet 1_Prevalence and correlates of depression and depression-anxiety in patients receiving gastroscopy.xlsx

ObjectiveThere are increasing numbers of patients suffering from gastrointestinal disorders who are at primary risk for depression. These patients often have no awareness of their depression and therefore choose to see their gastroenterologists. Normally gastroenterologists advise the patients to undergo gastroscopy to investigate their possible digestive disorders while overlooking their depression. This study investigated the prevalence of the comorbidities between depression, depression-anxiety and organic diseases of upper gastrointestinal tract (UGI) among patients receiving gastroscopy in a large general hospital in China.
MethodsA total of 707 patients who agreed to recommendation for gastroscopy were investigated using the nine-item Patient Health Questionnaire (PHQ-9). The patients of PHQ-9 scores ≥10 were further interviewed using the Hamilton depressive scale (HAMD), Hamilton anxiety scale (HAMA) and DSM-IV to confirm the diagnosis.
ResultsAltogether, 412 patients were found to suffer from organic diseases of UGI based on the gastroscopy results. Of these, 51 patients and 34 were diagnosed with major depression and depression-anxiety respectively. The detection rate of depression by gastroenterologists was 3.92% while no depression-anxiety was diagnosed. Multiple logistic regression showed the course of disease, number of gastroscopies and age were significantly associated with major depression while educational level, income, age, and number of gastroscopies were significantly associated with depression-anxiety.
ConclusionThe comorbidities rates between depression, depression-anxiety and organic diseases of UGI are higher than the general population in China. However, the detection rates of the comorbidities by gastroenterologists are low.

【研究目的】近年来，罹患胃肠道疾病且处于抑郁高危状态的患者数量持续增长。此类患者大多未察觉自身存在抑郁问题，因而仅前往消化科就诊。常规情况下，消化科医师会建议患者接受胃镜检查以排查潜在的消化道器质性病变，却往往忽视了患者的抑郁情绪。本研究以中国某大型综合医院接受胃镜检查的患者为研究对象，探究抑郁、抑郁焦虑共病与上消化道（upper gastrointestinal tract, UGI）器质性疾病之间的共病患病率。
【研究方法】本研究共纳入707名同意接受胃镜检查建议的患者，采用九项患者健康问卷（PHQ-9，nine-item Patient Health Questionnaire）对其进行调查。对于PHQ-9评分≥10分的患者，进一步采用汉密尔顿抑郁量表（HAMD，Hamilton depressive scale）、汉密尔顿焦虑量表（HAMA，Hamilton anxiety scale）及《精神障碍诊断与统计手册第四版》（DSM-IV）进行访谈以明确诊断。
【研究结果】经胃镜检查结果证实，共计412名患者存在上消化道器质性疾病。其中，分别有51名与34名患者被确诊为重度抑郁及抑郁焦虑共病。消化科医师对抑郁的检出率仅为3.92%，且未检出任何抑郁焦虑共病病例。多因素logistic回归分析结果显示，病程、胃镜检查次数及年龄与重度抑郁显著相关；而受教育程度、收入水平、年龄及胃镜检查次数则与抑郁焦虑共病显著相关。
【研究结论】在中国普通人群中，抑郁、抑郁焦虑共病与上消化道器质性疾病之间的共病率高于一般人群，但消化科医师对上述共病的检出率仍处于较低水平。