Supplementary Material for: Developmental defects of enamel: a bibliometric analysis of the top 100 most-cited papers

Background: Developmental Defects of Enamel (DDE) are a result of disturbances during formation and maturation of the enamel. Evaluating the most-cited DDE papers can provide important tools that point to the gaps and strengths of this important topic.
Summary: This bibliometric study analyzed the 100 most-cited papers on DDE. Using a combined keyword search strategy, the 100 most-cited papers in the Web of Science Core Collection (WoS-CC) were selected. Papers that addressed any type of DDE were included. The extracted data were title, number of citations, study theme, authorship, journal, type of DDE, type of dentition (primary or permanent), type of diagnosis, study design, year and country of publication. The bibliometric networks were generated through VOSviewer software. The 100 papers had a range from 78 to 459 citations. The main themes of studies were etiopathogenesis (53%), prevalence and incidence (22%) and diagnosis (8%). The author with the highest number of citations were Goodman AH and Rose JC (459 citations). Most articles were published in dental journals (47%). The most studied types of DDE were fluorosis and amelogenesis imperfecta in the permanent dentition (47%). Observational (24%) and non-systematic reviews (24%) were the most common study designs and ranged from 1977 to 2019. The country with the highest number of citations was the USA (40%).
Key messages: Most of the top 100 DDE papers were about fluorosis and amelogenesis imperfecta, with top papers from three continents with English as the native language. This topic is of great importance in dentistry, and the need for further studies is highlighted, especially regarding the diagnosis and treatment of some DDEs.

背景：牙釉质发育缺陷（Developmental Defects of Enamel, DDE）是牙釉质形成与成熟过程中受到干扰所引发的病变。对该领域高被引论文进行分析，可为明确这一重要研究主题的优势与不足提供关键参考工具。
摘要：本项文献计量学研究分析了牙釉质发育缺陷领域的100篇最高被引论文。采用组合关键词检索策略，从Web of Science核心合集（Web of Science Core Collection, WoS-CC）中筛选出符合要求的100篇高被引论文，纳入所有涉及各类牙釉质发育缺陷的研究。提取的研究数据包括论文标题、被引频次、研究主题、作者署名、刊载期刊、牙釉质发育缺陷类型、牙列类型（乳牙列或恒牙列）、诊断方式、研究设计、发表年份及发表国家。借助VOSviewer软件构建文献计量网络。该100篇论文的被引频次区间为78至459次。研究的核心主题依次为发病机制（53%）、流行率与发病率（22%）以及诊断方法（8%）。被引总次数最高的作者为Goodman AH与Rose JC（总被引459次）。近半数论文（47%）刊载于牙科专业期刊。研究关注度最高的牙釉质发育缺陷类型为恒牙列氟牙症与牙釉质发育不全（占比47%）。观察性研究（24%）与非系统性综述（24%）为最常见的研究设计，研究发表时间跨度为1977年至2019年。总被引频次最高的发表国家为美国（占比40%）。
核心要点：该领域Top100高被引论文大多聚焦于氟牙症与牙釉质发育不全，顶尖研究成果源自以英语为母语的三大洲。该主题在牙科学领域具有重要研究价值，研究结果凸显了开展进一步研究的必要性，尤其是针对部分牙釉质发育缺陷的诊断与治疗方向。