Genome-wide map of binding sites for HNF4a during hepatic specification of iPS cells. Genome-wide map of binding sites for HNF4a during hepatic specification of iPS cells

HNF4a has been shown to be critical for hepatocyte differentiation from iPS cells. Overall design: Chip-seq was performed on chromatin isolated from iPS cells differentiated to the onset of hepatic specification (day 8).

已有研究证实，肝细胞核因子4α（HNF4a）在诱导多能干细胞（iPS cells）向肝细胞的分化过程中发挥关键作用。实验设计：对诱导至肝系特化起始阶段（第8天）的诱导多能干细胞所提取的染色质，进行了染色质免疫共沉淀测序（Chip-seq）实验。