Center for Common Disease Genomics [CCDG] - Cardiovascular ATVB: Atherosclerosis Thrombosis and Vascular Biology

Italian Atherosclerosis Thrombosis and Vascular Biology study is a prospective, nationwide, case-control study involving 125 coronary care units in Italy. The cases were patients who were hospitalised for a first MI before the age of 45 years and underwent coronary angiography. Acute MI was defined as resting chest pain lasting more than 30 minutes, accompanied by persistent electrocardiographic changes, and confirmed by an increase in total creatine kinase or in the MB fraction to more than twice the upper normal limits. The controls were healthy subjects without a history of thromboembolic disease who were unrelated to the patients, but individually matched with them by age, gender and geographical origin. They were enrolled from among the blood donors or staff of the same participating hospitals. Recruitment of cases and controls took place between 1994 and 2007.

This site hosts data from ~60 whole exomes.

意大利动脉粥样硬化血栓形成与血管生物学研究（Italian Atherosclerosis Thrombosis and Vascular Biology study）是一项前瞻性、全国性病例对照研究，覆盖意大利境内125个冠心病监护病房（coronary care units）。病例组为45岁前因首次心肌梗死（myocardial infarction, MI）住院并接受冠状动脉造影（coronary angiography）的患者。急性心肌梗死（acute MI）的判定标准为：静息状态下胸痛持续时长超过30分钟，伴随持续性心电图改变，且血清总肌酸激酶或MB同工酶活性升高至正常上限两倍及以上。对照组为无血栓栓塞性疾病病史、与病例无亲缘关系的健康受试者，按年龄、性别及地域来源与病例进行个体匹配，招募自参与本研究的合作医院的献血者或院内职工。病例与对照的招募工作于1994年至2007年间开展。本平台收录约60例全外显子组（whole exomes）测序数据。