Systematic Review Data

Doctors have began to harness physical exercise's ability to promote positive postsynaptically-mediated plasticity to treat a range of disorder from genetic disorders such as Huntington's disease to mood disorders such as Major Depression Disorder (MDD). For this reason the understanding the relationship between physical exercise and neuroplasticity is an important endeavour as it gives doctors a non-pharmaceutical treatment option for many diseases. Thus a systematic review was conducted on Web of Science from 2010 to 2015 using the following terms 'neuroplasticity', 'brain', 'change*', 'exercise'. Articles were the only document types extracted, reviews, clinical trials, case reports, and abstract were all excluded. In addition only articles from the top five research domain in terms of published works were extracted. These reasearch domains included 'Neuroscience and Neurology', 'Biochemistry and Molecular Biology', 'Physiology', 'Psychology' and 'Psychiatry'. This resulted in 200 studies being extracted that were then individually reviewed to assess their relevance (Appendix). From the 200 articles studies were include in the final review if: (1) the study tested specifically the relationship between physical exercise and brain change, (2) the study used a manipulative approach methodology (3) target population of the study group were humans (4) the study was in English. Articles were excluded from the final review if: (1) the study tested the relationship between brain change with other stimuli other stimuli such as music in combination with physical activity, and (2) the study combined different types of exercise and measured the outcome as combination of the effects of these exercises.The 62 articles that met the inclusion criteria was systematically analyzed to: (1) see the type of exercise that was used in study, (2) Whether the gray matter volume, neurotorphic factor, executive function, or white matter volume was mesured in study, (3) the state of teh experimental subjects used in study.临床医生已开始利用体育锻炼促进突触后介导的正向神经可塑性（neuroplasticity）的能力，以治疗多种病症，涵盖亨廷顿病这类遗传性疾病，以及重性抑郁障碍（Major Depression Disorder, MDD）这类心境障碍。正因如此，厘清体育锻炼与神经可塑性之间的关联是一项极具价值的研究课题，因为它能为临床医生提供针对多种疾病的非药物治疗方案。因此，本研究于2010年至2015年间在Web of Science数据库中开展系统综述，检索式包含关键词：'neuroplasticity'、'brain'、'change*'、'exercise'。本次检索仅提取期刊论文作为目标文献类型，同时排除综述、临床试验、病例报告及摘要类文献。此外，仅纳入按发文量排名前五的研究领域的文献，这五个领域分别为：神经科学与神经病学（Neuroscience and Neurology）、生物化学与分子生物学（Biochemistry and Molecular Biology）、生理学（Physiology）、心理学（Psychology）及精神病学（Psychiatry）。最终共检索得到200项研究，随后由研究者逐一评审以评估其相关性（详见附录）。从这200篇文献中，最终纳入本综述的研究需满足以下全部条件：(1) 专门探究体育锻炼与大脑变化之间的关联；(2) 采用操纵性实验方法；(3) 研究对象为人类；(4) 文献语言为英语。若研究满足以下任一条件则被排除：(1) 探究大脑变化与运动结合其他刺激（如音乐）之间的关联；(2) 同时采用多种运动类型，并将多种运动的综合效应作为观测结局。最终共有62篇符合纳入标准的文献，本综述对其开展系统分析，分析维度包括：(1) 研究所采用的运动类型；(2) 研究中是否观测了灰质体积、神经营养因子（neurotrophic factor）、执行功能或白质体积；(3) 研究中实验受试者的基本状态。