EryDB

Erythropoiesis is a finely regulated and complex process that involves multiple transformations from hematopoietic stem cells to mature red blood cells at hematopoietic sites from the embryonic to the adult stages. Investigations into its molecular mechanisms have generated a wealth of expression data, including bulk and single-cell RNA sequencing data. A comprehensively integrated and well-curated erythropoiesis-specific database will greatly facilitate the mining of gene expression data and enable large-scale research of erythropoiesis and erythroid-related diseases. Here, we present EryDB, an open-access and comprehensive database dedicated to the collection, integration, analysis, and visualization of transcriptomic data for erythropoiesis and erythroid-related diseases. Currently, the database includes expertly curated quality-assured data of 3803 samples and 1,187,119 single cells derived from 107 public studies of three species (Homo sapiens, Mus musculus, and Danio rerio), nine tissue types, and five diseases. EryDB provides users with the ability to not only browse the molecular features of erythropoiesis between tissues and species, but also perform computational analyses of single-cell and bulk RNA sequencing data, thus serving as a convenient platform for customized queries and analyses. EryDB v1.0 is freely accessible at https://ngdc.cncb.ac.cn/EryDB/home.红细胞生成（Erythropoiesis）是一项受精细调控的复杂生物学过程，涵盖胚胎期至成年期造血位点中，造血干细胞向成熟红细胞的一系列转化过程。针对其分子机制的相关研究已产生海量表达谱数据，包括批量RNA测序（bulk RNA sequencing）与单细胞RNA测序（single-cell RNA sequencing）数据。一款经过全面整合与专家精心注释的红细胞生成专属数据库，将极大助力基因表达数据的挖掘工作，并为红细胞生成及红细胞系相关疾病的大规模研究提供重要支撑。在此我们推出EryDB——一款开放获取的综合性数据库，专门用于收集、整合、分析并可视化红细胞生成及红细胞系相关疾病的转录组数据。目前，该数据库收录了来自107项公开研究的、经过专家精心整理且质量验证的数据，涵盖3803个样本与1187119个单细胞，涉及3个物种（智人（Homo sapiens）、小家鼠（Mus musculus）及斑马鱼（Danio rerio））、9种组织类型与5种疾病。EryDB不仅可支持用户浏览不同组织与物种间红细胞生成的分子特征，还能对单细胞及批量RNA测序数据进行计算分析，从而成为一款便于用户开展定制化查询与分析的便捷平台。EryDB v1.0可通过https://ngdc.cncb.ac.cn/EryDB/home免费访问。