Methods for the large-scale synthesis of psoralen furan-side monoadducts and diadducts.
收藏PubMed Central1992-05-15 更新2026-05-16 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC49113/
下载链接
链接失效反馈官方服务：
资源简介：
We report methods for the preparation of multimicromole quantities of extremely pure uniquely photo-adducted psoralen-DNA furan-side monoadducts and diadducts (cross-links). The methods use high-intensity krypton and argon ion lasers in the photoreactions and HPLC methods to purify the required oligonucleotides containing the photoadducts. With these methods we have synthesized 2-3 mumol of 8-mer psoralen furan-side monoadduct and diadduct. These methods allow one to generate large amounts of psoralenated DNA oligonucleotides and facilitate their study by NMR and x-ray crystallography. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1992-05-15
