Nuclear cGAS synergistically orchestrates VEGF-mediated angiogenesis

Cyclic GMP-AMP synthase (cGAS) is a well-known cytosolic DNA sensor that activates innate immune responses by activating STING signal, which potentially mediates protective immune defense against infection. However, the mechanisms of nuclear translocation of cGAS, and the potential functions of nuclear cGAS signaling, which seems not to be involved in cGAS-STING pathway, have remained undetermined.

环GMP-AMP合酶（Cyclic GMP-AMP synthase, cGAS）是公认的经典胞质DNA感受器，可通过激活STING信号通路触发固有免疫应答，进而潜在介导针对感染的保护性免疫防御。然而，cGAS的核转位机制，以及似乎不参与cGAS-STING通路的核定位cGAS信号通路的潜在功能，目前仍未明确。