Supplementary Material for: Stiff-person syndrome with anti-amphiphysin antibodies: a paraneoplastic phenomenon revealing breast cancer in a 77-year old male

Introduction
Stiff-person syndrome is a neurological disorder characterized by painful muscle cramps and progressive muscle spasticity. In patients with positive anti-amphiphysin antibodies, there is an association with malignancies such as breast carcinomas and small cell lung cancers.

Case Presentation
We report the case of a 77-year-old male patient who developed symptoms of anti-amphiphysin positive stiff-person syndrome and was diagnosed with breast cancer. After immunomodulatory and curative-intent oncological treatment, the patient experienced marked improvement of his neurological symptoms.

Conclusion
This case is an example of the importance of multidisciplinary care and thorough oncological workup in a case of stiff-person syndrome with positive anti-amphiphysin antibodies.

引言
僵人综合征（Stiff-person syndrome）是一类以痛性肌肉痉挛及进行性肌肉强直为特征的神经系统疾病。抗两亲蛋白抗体阳性的该类患者，常与乳腺癌、小细胞肺癌等恶性肿瘤存在关联。

病例报告
本文报告1例77岁男性患者，出现抗两亲蛋白抗体阳性僵人综合征的相关症状，同时确诊乳腺癌。经免疫调节治疗与根治性肿瘤治疗后，患者神经系统症状获得显著改善。

结论
本案例充分体现了针对抗两亲蛋白抗体阳性僵人综合征患者，实施多学科协作诊疗与全面肿瘤排查评估的重要价值。