Data from: Designer self-assembling hydrogel scaffolds can impact skin cell proliferation and migration

There is a need to develop economical, efficient and widely available therapeutic approaches to enhance the rate of skin wound healing. The optimal outcome of wound healing is restoration to the pre-wound quality of health. In this study we investigate the cellular response to biological stimuli using functionalized nanofibers from the self-assembling peptide, RADA16. We demonstrate that adding different functional motifs to the RADA16 base peptide can influence the rate of proliferation and migration of keratinocytes and dermal fibroblasts. Relative to unmodified RADA16; the Collagen I motif significantly promotes cell migration, and reduces proliferation.

目前亟需开发经济高效、可及性广泛的治疗手段，以提升皮肤伤口愈合速率。伤口愈合的理想结局是使受损组织恢复至伤前的健康状态。本研究采用自组装肽（self-assembling peptide）RADA16制备的功能化纳米纤维，探究细胞对生物刺激的应答反应。研究证实，在RADA16基础肽段上引入不同功能基序，可影响角质形成细胞与真皮成纤维细胞的增殖与迁移速率。相较于未修饰的RADA16，I型胶原（Collagen I）功能基序可显著促进细胞迁移并抑制细胞增殖。