Move Yourself—Physical Exercise for Older Adults with Alzheimer’s Disease

This dataset derives from a non-randomized controlled trial with pre–post measurements that investigated the effects of a multimodal physical exercise program on older adults with Alzheimer’s disease (AD). The study was conducted in Uberaba, Minas Gerais, Brazil, and initially screened 50 community-dwelling participants diagnosed with AD by a neurologist. After applying inclusion and exclusion criteria, 23 participants were included and distributed across three groups: an exercise group with AD (n = 7), an AD control group (n = 8), and a cognitively healthy control group (n = 8). The intervention group participated in the university extension project “Move Yourself—Physical Exercise for Older Adults with Alzheimer’s Disease.” Cognitive, functional, and biochemical outcomes (BDNF and IL-2) were assessed before and after the intervention. All evaluations were conducted by trained assessors blinded to group allocation to ensure measurement reliability.本数据集源自一项采用前后测设计的非随机对照试验，旨在探究多模式体育锻炼方案对阿尔茨海默病（Alzheimer’s Disease, AD）老年患者的干预效果。本研究于巴西米纳斯吉拉斯州乌贝兰迪亚开展，最初由神经内科医师对50名社区居住的AD确诊患者进行了筛查。经纳入与排除标准筛选后，最终纳入23名受试者，并将其分为三组：AD运动干预组（n=7）、AD对照组（n=8）以及认知健康对照组（n=8）。干预组参与了大学推广项目"动起来——面向阿尔茨海默病老年患者的体育锻炼"。研究人员于干预前后对受试者的认知、功能及生化结局指标（脑源性神经营养因子BDNF与白细胞介素2 IL-2）进行了评估，所有评估均由经过培训且对分组分配设盲的评估人员完成，以保障测量信度。