Pancreatic cancer cell CFPAC-1: shBACH1 vs. shControl. Pancreatic cancer cell CFPAC-1: shBACH1 vs. shControl

Gene expression profiling of pancreatic cancer cell CFPAC-1 when BACH1 knockdown. BACH1 is a transcription repressor and its regulation networks is poorly understood in pancreatic ductal adenocarcinoma. We used the total RNA from shControl and shBACH1 CFPAC-1 cells to analyze the differentially expressed genes which were regulated by BACH1, and further explored the biological processes that BACH1 may involved. Overall design: Two-condition experiment, shBACH1 vs. shControl CFPAC1 cells. Biological replicates: 1 shBACH1 cell, 1 shControl cell.

本数据集针对BACH1敲低（BACH1 knockdown）条件下胰腺癌细胞CFPAC-1的基因表达谱展开分析。BACH1是一类转录抑制因子，但其在胰腺导管腺癌（pancreatic ductal adenocarcinoma）中的调控网络仍未得到充分解析。本研究利用短发夹RNA对照（shControl）与靶向BACH1的短发夹RNA（shBACH1）处理的CFPAC-1细胞总RNA，分析受BACH1调控的差异表达基因，并进一步探究BACH1可能参与的生物学过程。实验整体设计：采用双条件实验方案，对比shBACH1处理组与shControl处理组的CFPAC-1细胞。生物学重复设置：每组各设置1份生物学重复样本。